Key Takeaways Semaglutide, Tirzepatide, and Retatrutide are GLP-1 (glucagon-like peptide-1) medications, each offering increasing efficacy through multi-receptor targeting
I have tried nasal and sublingual sprays, sublingual lozenges and patches
For a 5mg vial: Add 2.5ml bacteriostatic water Resulting concentration: 2mg/ml (2000mcg/ml) For a 100mcg dose: draw 0.05ml (5 units on a standard insulin syringe) For a 200mcg dose: draw 0.10ml (10 units) For a 10mg vial: Add 3.0ml bacteriostatic water Resulting concentration: 3.33mg/ml (3333mcg/ml) For a 100mcg dose: draw 0.03ml (3 units) For a 200mcg dose: draw 0.06ml (6 units) Alternatively, for easier math with a 5mg vial, you can add 5ml of bacteriostatic water to create a 1mg/ml (1000mcg/ml) concentration
Injection site reactions Minor redness, tenderness, or slight swelling where you injected
With maintenance PPI therapy, the rate of relapse of esophagitis is 20% or less, which is lower than with H2 blockers (Figure 1.13)
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